6,750 research outputs found

    Cosa rimane dei subalterni alla luce dello ‘Stato integrale’?

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    Nei Quaderni del carcere Antonio Gramsci sviluppa un nuovo concetto di classi o gruppi sociali subalterni, utilizzato per caratterizzare tutti quei gruppi sociali che sono soggetti a forme di comando e di direzione politica e sociale imposto da altre classi, dominanti o dirigenti. Convertito al singolare, il concetto di “subalterno” è una di quelle nozioni originariamente gramsciane, che ha goduto grande successo a livello internazionale, soprattutto negli ultimi anni. Esso ha dato origine a un intero campo di ricerca accademica – i Subaltern Studies – affermando Gramsci come uno dei suoi “padri-teorici” più significativi. Oggi questo concetto gode di una diffusione disciplinare e di un riconoscimento diffusi tra giovani studiosi e studiose, in maniera paragonabile al concetto di egemonia; addirittura, in alcuni casi, il concetto di “subalterno” è considerato ancora più significativo rispetto al concetto, ad esso integralmente connesso, di egemonia, dal quale è talvolta visto come distinto ed indipendente, se non addirittura con esso posto in antagonismo

    The CCD and readout electronics for the OMC instrument on Integral

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    The Optical Monitoring Camera (OMC) on ESA's Integral gamma-ray astronomy satellite is devoted to optical wavelength observations simultaneously covering the same field-of-view as the gamma-ray and X-ray instruments. The OMC consists of a refracting telescope with a CCD as the imaging device in the focal plane. Here we describe the CCD and its associated readout electronics, in particular pointing out features of interest to users of the OMC instrument and its data

    Identification of the main glutamine and glutamate transporters in Staphylococcus aureus and their impact on c-di-AMP production

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    A Staphylococcus aureus strain deleted for the c‐di‐AMP cyclase gene dacA is unable to survive in rich medium unless it acquires compensatory mutations. Previously identified mutations were in opuD, encoding the main glycine‐betaine transporter, and alsT, encoding a predicted amino acid transporter. Here, we show that inactivation of OpuD restores the cell size of a dacA mutant to near wild‐type (WT) size, while inactivation of AlsT does not. AlsT was identified as an efficient glutamine transporter, indicating that preventing glutamine uptake in rich medium rescues the growth of the S. aureus dacA mutant. In addition, GltS was identified as a glutamate transporter. By performing growth curves with WT, alsT and gltS mutant strains in defined medium supplemented with ammonium, glutamine or glutamate, we revealed that ammonium and glutamine, but not glutamate promote the growth of S. aureus. This suggests that besides ammonium also glutamine can serve as a nitrogen source under these conditions. Ammonium and uptake of glutamine via AlsT and hence likely a higher intracellular glutamine concentration inhibited c‐di‐AMP production, while glutamate uptake had no effect. These findings provide, besides the previously reported link between potassium and osmolyte uptake, a connection between nitrogen metabolism and c‐di‐AMP signalling in S. aureus

    Examining a staging model for anorexia nervosa: empirical exploration of a four stage model of severity.

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    Background: An illness staging model for anorexia nervosa (AN) has received increasing attention, but assessing the merits of this concept is dependent on empirically examining a model in clinical samples. Building on preliminary findings regarding the reliability and validity of the Clinician Administered Staging Instrument for Anorexia Nervosa (CASIAN), the current study explores operationalising CASIAN severity scores into stages and assesses their relationship with other clinical features. Method: In women with DSM-IV-R AN and sub-threshold AN (all met AN criteria using DSM 5), receiver operating curve (ROC) analysis (n = 67) assessed the relationship between the sensitivity and specificity of each stage of the CASIAN. Thereafter chi-square and post-hoc adjusted residual analysis provided a preliminary assessment of the validity of the stages comparing the relationship between stage and treatment intensity and AN sub-types, and explored movement between stages after six months (Time 3) in a larger cohort (n = 171). Results: The CASIAN significantly distinguished between milder stages of illness (Stage 1 and 2) versus more severe stages of illness (Stages 3 and 4), and approached statistical significance in distinguishing each of the four stages from one other. CASIAN Stages were significantly associated with treatment modality and primary diagnosis, and CASIAN Stage at Time 1 was significantly associated with Stage at 6 month follow-up. Conclusions: Provisional support is provided for a staging model in AN. Larger studies with longer follow-up of cases are now needed to replicate and extend these findings and evaluate the overall utility of staging as well as optimal staging models
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